Understanding cellular pathway alterations underlying phenotypic differences in rad9-deficient Saccharomyces cerevisiae with altered SAM gene mutations.

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Northern Kentucky University
SAM1 and SAM2 genes encode for an enzyme that produces S-Adenosylmethionine (AdoMet), a methyl donor in S. cerevisiae. Previous experiments have demonstrated these genes affect chromosome stability and AdoMet availability. rad9-deficient strains were used to understand the effects on cells predisposed to an aneuploid state. Growth differences were assessed between our rad9-control and mutant strains in 1,400 conditions. We are currently studying altered growth in 201 conditions with 43 different mechanisms of action to understand how the altered conditions and SAM gene status impact cellular pathways.
2020 Celebration of Student Research and Creativity presentation
Saccharomyces cerevisiae , Mutation, Genes, Cells