Microwave Irradiation of Heteroaryl Compounds with Tropinone for the Synthesis of Aromatase Inhibitors
Northern Kentucky University
"Heteroaryl compounds are important molecules with extensive significance in medical chemistry. In our lab, we reacted heteroaryl compounds (4- Bromoquinolone) with tropinone using microwave irradiation at 160°C and 180°C in the presence of palladium catalyst. Techniques such as NMR, MPLC, and computer modeling were then utilized to isolate and purify the compound as well as assess its potential as an orally active drug. Overall, this research is significant because the product obtained could possibly serve as an aromatase inhibitor which would help in the treatment of breast cancer patients."
2021 Celebration of Student Research and Creativity presentation
Heterocyclic compounds, Education research laboratories, Cancer Research