Determining Important Residues in THADA Responsible for the Methylation of Residue 32 in tRNAs

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dc.contributor.authorWehrle, Kendal
dc.date.accessioned2021-08-19T14:57:04Z
dc.date.available2021-08-19T14:57:04Z
dc.date.created2020
dc.description2020 Celebration of Student Research and Creativity presentationen_US
dc.description.abstractPost-transcriptional modifications of tRNAs are important for their biological function. Modifications in or around the anticodon loop of tRNA aid in translation, while modifications in the body aid in its stability. Yeast Trm7 methyltransferase methylates residues 32 (C32) and 34 (N34) of tRNAs in yeast. Trm732 is a binding partner of Trm7 and must be bound for methylation of C32 to occur. THADA is the human ortholog of the yeast protein Trm732. THADA alleles are associated with type II diabetes and polycystic ovary syndrome. The goal of this research is to determine region(s) of THADA required for methylation of C32.en_US
dc.description.urihttps://youtu.be/9Wt2gZoikDsen_US
dc.identifier.urihttp://hdl.handle.net/11216/3943
dc.language.isoen_USen_US
dc.publisherNorthern Kentucky Universityen_US
dc.relation.ispartofseriesCelebration of Student Research and Creativity;2020
dc.subjectTransfer RNAen_US
dc.subjectAnticodoneen_US
dc.subjectYeasten_US
dc.subjectProteinsen_US
dc.titleDetermining Important Residues in THADA Responsible for the Methylation of Residue 32 in tRNAsen_US
dc.typePresentationen_US

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