Identification of Residues Required for Trm732 tRNA Modification Activity in Yeast

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dc.contributor.authorVogel, Michaela
dc.date.accessioned2021-04-15T18:39:22Z
dc.date.available2021-04-15T18:39:22Z
dc.date.created2020
dc.description2020 Celebration of Student Research and Creativity presentation.en_US
dc.description.abstractModifications of tRNA are critical for proper functioning. Yeast Trm7 is an enzyme that interacts with Trm732 and Trm734 to modify tRNAs at residues C32 and G34, respectively. Yeast mutants lacking both Trm732 and Trm734 are sick, indicating that these proteins are required for proper cell growth. By measuring tRNA nucleoside modification levels with UPLC Trm732 can be quantitively analyzed. Qualitatively Trm732 can be analyzed through growth assays. Variations in the human homolog of Trm732, THADA, have been linked to polycystic ovary syndrome and type.en_US
dc.description.urihttps://youtu.be/UVceDvG4znken_US
dc.identifier.urihttp://hdl.handle.net/11216/3701
dc.language.isoen_USen_US
dc.publisherNorthern Kentucky Universityen_US
dc.relation.ispartofseriesCelebration of Student Research and Creativity;2020
dc.subjectTransfer RNAen_US
dc.subjectEnzyme synthesisen_US
dc.subjectProteins Synthesisen_US
dc.titleIdentification of Residues Required for Trm732 tRNA Modification Activity in Yeasten_US
dc.typePresentationen_US

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