Synthesis of alpha- heteroaryl Compounds via Palladium Catalysis in Course-based Undergraduate Research Experience (CURE) Organic Lab

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dc.contributor.authorWilliams, Donald
dc.contributor.authorTrejo, Jasmine
dc.date.accessioned2021-10-27T18:32:12Z
dc.date.available2021-10-27T18:32:12Z
dc.date.created2020
dc.description2020 Celebration of Student Research and Creativity presentationen_US
dc.description.abstract" Heteroaryl compounds are common and important components in medicinal chemistry. A palladium catalyzed α-heteroarylation of the compound tropinone under microwave irradiation was conducted in our lab. In this presentation, the palladium catalysis was utilized to synthesize α- heteroaryl compounds. The optimized reaction conditions are 1.1 equivalents of tropinone, 1 equivalent of heteroaryl halide, 2.4 equivalents of NaOtBu. 2mol% of XPhos Pd, in a 2mL toluene solution under microwave irradiation for 20 minutes at 1500 C. This study provided data and information for the development and manufacture of new heteroaryl compounds as cancer treatment candidates."en_US
dc.description.urihttps://nku.voicethread.com/share/16257715/en_US
dc.identifier.urihttp://hdl.handle.net/11216/4092
dc.language.isoen_USen_US
dc.publisherNorthern Kentucky Universityen_US
dc.relation.ispartofseriesCelebration of Student Research and Creativity;2020
dc.subjectPharmaceutical chemistryen_US
dc.subjectPalladium catalystsen_US
dc.subjectCancer Treatmenten_US
dc.titleSynthesis of alpha- heteroaryl Compounds via Palladium Catalysis in Course-based Undergraduate Research Experience (CURE) Organic Laben_US
dc.typePresentationen_US

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