Synthesis Reaction between Tropinone and Heteroaryl Compounds to Create Aromatase Inhibitors

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dc.contributor.authorNguyen, Binh
dc.date.accessioned2021-11-17T20:07:30Z
dc.date.available2021-11-17T20:07:30Z
dc.date.created2021
dc.description2021 Celebration of Student Research and Creativity presentationen_US
dc.description.abstractHeteroaryl compounds are one of the most valuable compounds that can be used to benefit the pharmaceutical industry. The reaction between heteroaryl compounds with tropinone will potentially create bioactive products - heteroaryl tropinone, which can help to make aromatase inhibitors. These inhibitors are then used to apply in the process of curing breast cancer. In our research, each individual was given certain heteroaryl compounds such as 4- bromo-1H indazole(H44), 6bromoquinoline (H40), 5- iodo-1H-idazole (HIH45) to run the reaction using the microwave irradiation method. After that, the product went through the process of simple workup (acetone centrifuge), purification ( acid-base extraction, rotavap), and characterization (NMR). To identify the bioactive of the pure product, we utilized computer modeling to predict the inhibitor interaction. The successful molecule will be submitted for further analysis as contributing to the medication and education in the organic research field.en_US
dc.description.urihttps://youtu.be/wjeqSIzGViwen_US
dc.identifier.urihttp://hdl.handle.net/11216/4168
dc.language.isoen_USen_US
dc.publisherNorthern Kentucky Universityen_US
dc.relation.ispartofseriesCelebration of Student Research and Creativity;2021
dc.subjectHeterocyclic compoundsen_US
dc.subjectBreast Canceren_US
dc.subjectPharmaceutical chemistryen_US
dc.titleSynthesis Reaction between Tropinone and Heteroaryl Compounds to Create Aromatase Inhibitorsen_US
dc.typePresentationen_US

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