Acetone Centrifugation and Acid/Base Work Up for Palladium-catalyzed Heteroarylation of Ketones Reaction

Abstract

"The research belongs to the CURE program which exposes students to research. 2.5 million women in the US are currently fighting against breast cancer. Fortunately, placental aromatase cytochrome exists an active site that is potential for interacting with drug inhibitors. Tropinone derivatives (I80-H40, I80- H44, and I80-HIH45) were synthesized using the microwave to yield H- bonding and interaction with the Heme group in aromatase. The reaction is catalyzed by Palladium catalysis to prevent (bishero)arylation. During the process, a new work up method by acetone and acid/base wash was found to yield a better purification of the product."