URROC- Undergraduate Research in Organic Chemistry Course Synthesis of Heteroaryl Molecule I80-H53 through Palladium Catalyzed Heteroarylation
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Northern Kentucky University
Abstract
"Our research focused on the properties of several heteroaryl molecules which had never been synthesized in the hopes that they will help find better treatment for breast cancer. 2.4 NaOtBu, 2% XPhos Pd Gen 4, 1.1 tropinone (I80), 1 heteroaryl (H53), and 2 mL of toluene molar equivalents were used in the synthesis. This mixture underwent microwave irradiation to produce the heteroaryl tropinone product. This product was purified using acetone centrifugation and acid-base extraction and then identified using NMR. The synthesized molecule may be able to function as an aromatase inhibitor and help treat hormone receptor- positive breast cancer."
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2021 Celebration of Student Research and Creativity presentation
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Presentation
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Heterocyclic compounds, Breast Cancer Research, Education research laboratories