Synthesis of Heteroaryl Molecules Through Palladium-Catalyzed Heteroarylation
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Northern Kentucky University
Abstract
"Heteroaryl compounds are commonly used in medicinal chemistry. Most pharmaceuticals are made from heteroaryl compounds. The purpose of this project was to study bioactive heteroaryl compounds that could potentially be a breast cancer treatment due to its likelihood to inhibit aromatase, a pharmaceutical target for breast cancer. Through our research we reacted different heteroaryls with tropinone by microwave assisted, palladium- catalyzed direct heteroarylation. The products were then purified, identified, and evaluated by MPLC, NMR, and computer modeling. This study provided not only useful discoveries in cancer research, but also developments of CURE and UROCC labs for undergraduate chemistry students."
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2021 Celebration of Student Research and Creativity presentation
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Presentation
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Heterocyclic compounds, Breast Cancer, Cancer Treatment