Browsing by Creator "Nguyen, Binh"
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Item Acetone Centrifugation and Acid/Base Work Up for Palladium-catalyzed Heteroarylation of Ketones Reaction(Northern Kentucky University) Le, Thao Linh (Rosie); Nguyen, Binh"The research belongs to the CURE program which exposes students to research. 2.5 million women in the US are currently fighting against breast cancer. Fortunately, placental aromatase cytochrome exists an active site that is potential for interacting with drug inhibitors. Tropinone derivatives (I80-H40, I80- H44, and I80-HIH45) were synthesized using the microwave to yield H- bonding and interaction with the Heme group in aromatase. The reaction is catalyzed by Palladium catalysis to prevent (bishero)arylation. During the process, a new work up method by acetone and acid/base wash was found to yield a better purification of the product."Item Synthesis Reaction between Tropinone and Heteroaryl Compounds to Create Aromatase Inhibitors(Northern Kentucky University) Nguyen, BinhHeteroaryl compounds are one of the most valuable compounds that can be used to benefit the pharmaceutical industry. The reaction between heteroaryl compounds with tropinone will potentially create bioactive products - heteroaryl tropinone, which can help to make aromatase inhibitors. These inhibitors are then used to apply in the process of curing breast cancer. In our research, each individual was given certain heteroaryl compounds such as 4- bromo-1H indazole(H44), 6bromoquinoline (H40), 5- iodo-1H-idazole (HIH45) to run the reaction using the microwave irradiation method. After that, the product went through the process of simple workup (acetone centrifuge), purification ( acid-base extraction, rotavap), and characterization (NMR). To identify the bioactive of the pure product, we utilized computer modeling to predict the inhibitor interaction. The successful molecule will be submitted for further analysis as contributing to the medication and education in the organic research field.