NKU Course-Based Undergraduate Research Experience: The Identification of Potential Aromatase Inhibitors Based on Computer Modeling

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dc.contributor.authorSeibert, Samuel
dc.contributor.authorRoy, Ayanav
dc.contributor.authorUngar, Liat
dc.date.accessioned2021-12-08T18:31:06Z
dc.date.available2021-12-08T18:31:06Z
dc.date.created2021
dc.description2021 Celebration of Student Research and Creativity presentationen_US
dc.description.abstract"Microwave-assisted palladium catalyzed alpha- heteroarylation reactions were performed to join tropinone with heteroaryl halide compounds 4- bromoisoquinoline and 6- bromoquinoline to obtain potential aromatase inhibitors for the treatment of breast cancer. Computer modeling reveals that both target products show high enzyme-pocket docking scores compared to other tropinone-heteroaryl products synthesized in this course-based research lab. Herein, binding pocket interactions of various tropinone-derived compounds are compared to provide a rationale for further testing of these target products."en_US
dc.description.urihttps://youtu.be/VWKd8xXz-Uken_US
dc.identifier.urihttp://hdl.handle.net/11216/4193
dc.language.isoen_USen_US
dc.publisherNorthern Kentucky Universityen_US
dc.relation.ispartofseriesCelebration of Student Research and Creativity;2021
dc.subjectHeterocyclic compoundsen_US
dc.subjectEducation research laboratoriesen_US
dc.subjectCancer Researchen_US
dc.titleNKU Course-Based Undergraduate Research Experience: The Identification of Potential Aromatase Inhibitors Based on Computer Modelingen_US
dc.typePresentationen_US

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Student Research and Creativity