Heteroaryl Isoflavone compounds as aromatase inhibitors: Diketone Reaction Exploration

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Northern Kentucky University
The overall goal of the research conducted was to synthesize a potential aromatase inhibitor through a heteroarylation reaction. Previously, a diketone compound was synthesized through the course of our normal research. After a synthetic route was created and confirmed, work began to synthesize a library of diketone compounds. Products were synthesized through a two-step method, in which the compound was synthesized through our base reaction. Once the compound was confirmed by NMR, the second step involved the formation of the diketone under microwave irradiation. A library of successful products and their pure yields is reported in this poster.
2020 Celebration of Student Research and Creativity presentation
Ketones, Isoflavones, Aromatase