Development of Heteroaryl Compounds Targeting at Aromatase for Cancer Therapy

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dc.contributor.authorWehrle, Natalie
dc.date.accessioned2021-08-19T18:15:34Z
dc.date.available2021-08-19T18:15:34Z
dc.date.created2020
dc.description2020 Celebration of Student Research and Creativity presentationen_US
dc.description.abstractHeteroaryl compounds are valuable building blocks in medicinal chemistry and chemical industry. A palladium-catalyzed direct αC(sp3) heteroarylation of ketones under microwave irradiation was performed to synthesize isocoumarin derivatives. The optimized reaction conditions are as follows: 1.1 equivalents of ketone, 1 equivalent of heteroaryl halide, 2.4 equivalents of NaOtBu, XPhos Pd Gen 4 catalyst, toluene, MW 1300 C for 10 min. The final product was purified by medium pressure liquid chromatography (MPLC) and characterized by nuclear magnetic resonance (NMR). This study provided insightful information for the development of bioactive heteroaryl compoundsen_US
dc.description.urihttps://youtu.be/Spw5lvTpFXAen_US
dc.identifier.urihttp://hdl.handle.net/11216/3944
dc.language.isoen_USen_US
dc.publisherNorthern Kentucky Universityen_US
dc.relation.ispartofseriesCelebration of Student Research and Creativity;2020
dc.subjectAromataseen_US
dc.subjectCancer Treatmenten_US
dc.subjectKetonesen_US
dc.titleDevelopment of Heteroaryl Compounds Targeting at Aromatase for Cancer Therapyen_US
dc.typePresentationen_US

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Student Research and Creativity