Anticodon Loop Modifications Enhance Oxidative Stress Recovery in Yeast

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dc.contributor.authorSeibert, Samuel
dc.contributor.authorGuy, Michael P
dc.date.accessioned2021-10-27T14:42:33Z
dc.date.available2021-10-27T14:42:33Z
dc.date.created2020
dc.description2020 Celebration of Student Research and Creativity presentationen_US
dc.description.abstract"Across eukaryotic organisms, 2`-O methylations on the anticodon loops of tRNA molecules are widely conserved and crucial for efficient translation. The methyltransferase Trm7 interacts with the protein Trm732 to methylate nucleotide C32 and interacts with the protein Trm734 to methylate nucleotide G34 on tRNA phenylalanine. Yeast cells lacking both modifications are sick, but the presence of either modification causes a healthy phenotype. Oxidative stress caused by free radicals stimulates metabolic responses which upregulate the transcription of stress recovery genes. Previous research indicates that trm7Δ mutants and trm734Δ mutants have lowered resistance to oxidative stress. In this study,trm732Δ, trm734Δ and trm7Δ mutants showed lowered, yet comparable levels of oxidative stress resistance."en_US
dc.description.urihttps://youtu.be/GmpjXCQG5Foen_US
dc.identifier.urihttp://hdl.handle.net/11216/4084
dc.language.isoen_USen_US
dc.publisherNorthern Kentucky Universityen_US
dc.relation.ispartofseriesCelebration of Student Research and Creativity;2020
dc.subjectEukaryotic cellsen_US
dc.subjectTransfer RNAen_US
dc.subjectStress (Physiology)en_US
dc.subjectYeasten_US
dc.titleAnticodon Loop Modifications Enhance Oxidative Stress Recovery in Yeasten_US
dc.typePresentationen_US

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