Synthesis, Purification, and Computer Modeling of I80-H37

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dc.contributor.authorWright, Makayla
dc.date.accessioned2021-12-16T14:28:05Z
dc.date.available2021-12-16T14:28:05Z
dc.date.created2021
dc.description2021 Celebration of Student Research and Creativity presentationen_US
dc.description.abstract"Heteroaryl compounds have been shown to hold a prospective significance in pharmaceutical circumstances. I80 and H37 represent the molecules tropinone and 3- bromoquinolone, respectively. As such, this research focuses on the synthesis of heteroaryl compounds with a tropinone scaffold. Furthermore, the efficacy of these target compounds as an aromatase inhibitor can be analyzed. To predict this, computer modeling was utilized with relation to three major molecular interactions: hydrogen bonding, heme chelation, and hydrophobic interactions. Molecules that contain these interactions are thus an effective aromatase inhibitor. This is correspondingly reflected through the molecule’s docking score-- a higher score demonstrates stronger inhibiting properties."en_US
dc.description.urihttps://youtu.be/h-pywDy854Qen_US
dc.identifier.urihttp://hdl.handle.net/11216/4224
dc.language.isoen_USen_US
dc.publisherNorthern Kentucky Universityen_US
dc.relation.ispartofseriesCelebration of Student Research and Creativity;2021
dc.subjectHeterocyclic compoundsen_US
dc.subjectAromataseen_US
dc.subjectPharmaceutical chemistryen_US
dc.titleSynthesis, Purification, and Computer Modeling of I80-H37en_US
dc.typePresentationen_US

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Student Research and Creativity