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Investigation on the Synthesis, Application and Structural Features of Heteroaryl 1,2-Diketones

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dc.contributor.author Wehrle, Robert J.
dc.contributor.author Rosen, Alexander
dc.contributor.author Nguyen, Thu Vu
dc.contributor.author Koons, Kalyn
dc.contributor.author Jump, Eric
dc.contributor.author Bullard, Mason
dc.contributor.author Wehrle, Natalie
dc.contributor.author Stockfish, Adam
dc.contributor.author Hare, Patrick M.
dc.contributor.author Atesin, Abdurrahman
dc.contributor.author Ateşin, Tülay A.
dc.contributor.author Ma, Lili
dc.date.accessioned 2022-08-16T14:33:48Z
dc.date.available 2022-08-16T14:33:48Z
dc.date.issued 2022-08-02
dc.identifier.uri http://hdl.handle.net/11216/4293
dc.description.abstract A set of unsymmetrical heteroaryl 1,2-diketones were synthesized by a heteroarylation/oxidation sequence with up to 65% isolated yields. Palladium catalyst XPhos Pd G4 and SeO2 were the key reagents used in this methodology, and microwave irradiation was utilized to facilitate an efficient and ecofriendly process. The application of heteroaryl 1,2-diketones is demonstrated through the synthesis of an unsymmetrical 2-phenyl-3-(pyridin-3-yl)quinoxaline (5a) from 1-phenyl-2-(pyridin-3-yl)ethane-1,2-dione (4a). The lowest energy conformations of 4a and 5a were located using Density Functional Theory (DFT) at the M06-2X/def2-TZVP level of theory. Two lowest energy conformations of 4a differ with respect to the position of the N atom in the pyridyl ring and 0.27 kcal/mol energy difference between them corresponds to 60.4 and 39.6% at 50 °C in toluene. Four lowest energy conformations for 5a have the energy differences of 0.01, 0.03 and 0.07 kcal/mol that corresponds to 26.0, 25.7, 24.9 and 23.4%, respectively. A comparison of 4a and 5a to the less hindered analogs (oxalyl chloride and oxalic acid) is used to investigate the structural features and bonding using Natural Bond Orbital (NBO) analysis. en_US
dc.language.iso en_US en_US
dc.title Investigation on the Synthesis, Application and Structural Features of Heteroaryl 1,2-Diketones en_US
dc.type Article en_US


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