Investigation on the Synthesis, Application and Structural Features of Heteroaryl 1,2-Diketones

Simple item record
dc.contributor.authorWehrle, Robert J.
dc.contributor.authorRosen, Alexander
dc.contributor.authorNguyen, Thu Vu
dc.contributor.authorKoons, Kalyn
dc.contributor.authorJump, Eric
dc.contributor.authorBullard, Mason
dc.contributor.authorWehrle, Natalie
dc.contributor.authorStockfish, Adam
dc.contributor.authorHare, Patrick M.
dc.contributor.authorAtesin, Abdurrahman
dc.contributor.authorAteşin, Tülay A.
dc.contributor.authorMa, Lili
dc.date.accessioned2022-08-16T14:33:48Z
dc.date.available2022-08-16T14:33:48Z
dc.date.issued2022-08-02
dc.description.abstractA set of unsymmetrical heteroaryl 1,2-diketones were synthesized by a heteroarylation/oxidation sequence with up to 65% isolated yields. Palladium catalyst XPhos Pd G4 and SeO2 were the key reagents used in this methodology, and microwave irradiation was utilized to facilitate an efficient and ecofriendly process. The application of heteroaryl 1,2-diketones is demonstrated through the synthesis of an unsymmetrical 2-phenyl-3-(pyridin-3-yl)quinoxaline (5a) from 1-phenyl-2-(pyridin-3-yl)ethane-1,2-dione (4a). The lowest energy conformations of 4a and 5a were located using Density Functional Theory (DFT) at the M06-2X/def2-TZVP level of theory. Two lowest energy conformations of 4a differ with respect to the position of the N atom in the pyridyl ring and 0.27 kcal/mol energy difference between them corresponds to 60.4 and 39.6% at 50 °C in toluene. Four lowest energy conformations for 5a have the energy differences of 0.01, 0.03 and 0.07 kcal/mol that corresponds to 26.0, 25.7, 24.9 and 23.4%, respectively. A comparison of 4a and 5a to the less hindered analogs (oxalyl chloride and oxalic acid) is used to investigate the structural features and bonding using Natural Bond Orbital (NBO) analysis.en_US
dc.identifier.urihttp://hdl.handle.net/11216/4293
dc.language.isoen_USen_US
dc.titleInvestigation on the Synthesis, Application and Structural Features of Heteroaryl 1,2-Diketonesen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ao2c02914.pdf
Size:
3.23 MB
Format:
Adobe Portable Document Format
Description:
Article
Download

Collections

All Faculty Works