Browsing by Creator "Ungar, Liat"
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Item Microwave Irradiation of Heteroaryl Compounds with Tropinone for the Synthesis of Aromatase Inhibitors(Northern Kentucky University) Ungar, Liat; Seibert, Samuel"Heteroaryl compounds are important molecules with extensive significance in medical chemistry. In our lab, we reacted heteroaryl compounds (4- Bromoquinolone) with tropinone using microwave irradiation at 160°C and 180°C in the presence of palladium catalyst. Techniques such as NMR, MPLC, and computer modeling were then utilized to isolate and purify the compound as well as assess its potential as an orally active drug. Overall, this research is significant because the product obtained could possibly serve as an aromatase inhibitor which would help in the treatment of breast cancer patients."Item NKU Course-Based Undergraduate Research Experience: The Identification of Potential Aromatase Inhibitors Based on Computer Modeling(Northern Kentucky University) Seibert, Samuel; Roy, Ayanav; Ungar, Liat"Microwave-assisted palladium catalyzed alpha- heteroarylation reactions were performed to join tropinone with heteroaryl halide compounds 4- bromoisoquinoline and 6- bromoquinoline to obtain potential aromatase inhibitors for the treatment of breast cancer. Computer modeling reveals that both target products show high enzyme-pocket docking scores compared to other tropinone-heteroaryl products synthesized in this course-based research lab. Herein, binding pocket interactions of various tropinone-derived compounds are compared to provide a rationale for further testing of these target products."