Palladium-Catalyzed Direct α‑C(sp3) Heteroarylation of Ketones 2 under Microwave Irradiation

Simple item record
dc.contributor.authorQuillen, Andrew
dc.contributor.authorNguyen, Quynh
dc.contributor.authorNeiser, Matthew
dc.contributor.authorLindsay, Kara
dc.contributor.authorRosen, Alexander
dc.contributor.authorRamirez, Stephen
dc.contributor.authorCostan, Stefana
dc.contributor.authorJohnson, Nathan
dc.contributor.authorDo, Thuy Donna
dc.contributor.authorOscar, Rodriguez
dc.contributor.authorRivera, Diego
dc.contributor.authorAtesin, Abdurrahman
dc.contributor.authorAteşin, Tülay Aygan
dc.contributor.authorMa, Lili
dc.date.accessioned2022-09-02T14:29:53Z
dc.date.available2022-09-02T14:29:53Z
dc.date.issued2019-04-19
dc.description.abstractHeteroaryl compounds are valuable building blocks in medicinal chemistry and chemical industry. A palladium-catalyzed direct α-C(sp3) heteroarylation of ketones under microwave irradiation is developed and reported in this study. Under optimized conditions, twentyeight (28) heteroarylated ketones were prepared in this study to demonstrate the substrate scope of this reaction. The ground-state optimized structure of Pd(0) active catalyst with 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl (XPhos) in toluene, and the products of its reaction with 3-bromopyridine and acetophone were studied using all-atom density functional theory. This study provided insightful information for palladium catalytic system design to generate heteroaryl compounds.en_US
dc.identifier.urihttp://hdl.handle.net/11216/4294
dc.language.isoen_USen_US
dc.publisherAmerican Chemical Societyen_US
dc.titlePalladium-Catalyzed Direct α‑C(sp3) Heteroarylation of Ketones 2 under Microwave Irradiationen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
20190426 Proof-manuscript.pdf
Size:
1.81 MB
Format:
Adobe Portable Document Format
Description:
Download

Collections

All Faculty Works