Browsing by Creator "Wright, Makayla"
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Item Assessing the Contribution of the Glutamatergic System to Risky Choice(Northern Kentucky University) Wright, MakaylaRisky choice is characteristic of several psychological disorders, including addiction. Using the risky decision task (RDT), rats had the opportunity to choose a small, safe food reward or a large food, risky reward associated with a foot shock. To understand the neurochemical processes of risky choice as assessed in the RDT, rats received three NMDA receptor drugs: MK-801, Ro 63-1908, and CGS 19755. MK-801 hindered the rats’ ability to discriminate reinforcer magnitude, making it difficult for them to differentiate between the two presented options. Furthermore, CGS increased the rats’ risky behavior, while Ro 63 decreased risky choice in male rats.Item Synthesis, Purification, and Computer Modeling of I80-H37(Northern Kentucky University) Wright, Makayla"Heteroaryl compounds have been shown to hold a prospective significance in pharmaceutical circumstances. I80 and H37 represent the molecules tropinone and 3- bromoquinolone, respectively. As such, this research focuses on the synthesis of heteroaryl compounds with a tropinone scaffold. Furthermore, the efficacy of these target compounds as an aromatase inhibitor can be analyzed. To predict this, computer modeling was utilized with relation to three major molecular interactions: hydrogen bonding, heme chelation, and hydrophobic interactions. Molecules that contain these interactions are thus an effective aromatase inhibitor. This is correspondingly reflected through the molecule’s docking score-- a higher score demonstrates stronger inhibiting properties."