Browsing by Creator "Wehrle, Natalie"
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Item Development of Heteroaryl Compounds Targeting at Aromatase for Cancer Therapy(Northern Kentucky University) Wehrle, NatalieHeteroaryl compounds are valuable building blocks in medicinal chemistry and chemical industry. A palladium-catalyzed direct αC(sp3) heteroarylation of ketones under microwave irradiation was performed to synthesize isocoumarin derivatives. The optimized reaction conditions are as follows: 1.1 equivalents of ketone, 1 equivalent of heteroaryl halide, 2.4 equivalents of NaOtBu, XPhos Pd Gen 4 catalyst, toluene, MW 1300 C for 10 min. The final product was purified by medium pressure liquid chromatography (MPLC) and characterized by nuclear magnetic resonance (NMR). This study provided insightful information for the development of bioactive heteroaryl compoundsItem Investigation on the Synthesis, Application and Structural Features of Heteroaryl 1,2-Diketones(2022-08-02) Wehrle, Robert J.; Rosen, Alexander; Nguyen, Thu Vu; Koons, Kalyn; Jump, Eric; Bullard, Mason; Wehrle, Natalie; Stockfish, Adam; Hare, Patrick M.; Atesin, Abdurrahman; Ateşin, Tülay A.; Ma, LiliA set of unsymmetrical heteroaryl 1,2-diketones were synthesized by a heteroarylation/oxidation sequence with up to 65% isolated yields. Palladium catalyst XPhos Pd G4 and SeO2 were the key reagents used in this methodology, and microwave irradiation was utilized to facilitate an efficient and ecofriendly process. The application of heteroaryl 1,2-diketones is demonstrated through the synthesis of an unsymmetrical 2-phenyl-3-(pyridin-3-yl)quinoxaline (5a) from 1-phenyl-2-(pyridin-3-yl)ethane-1,2-dione (4a). The lowest energy conformations of 4a and 5a were located using Density Functional Theory (DFT) at the M06-2X/def2-TZVP level of theory. Two lowest energy conformations of 4a differ with respect to the position of the N atom in the pyridyl ring and 0.27 kcal/mol energy difference between them corresponds to 60.4 and 39.6% at 50 °C in toluene. Four lowest energy conformations for 5a have the energy differences of 0.01, 0.03 and 0.07 kcal/mol that corresponds to 26.0, 25.7, 24.9 and 23.4%, respectively. A comparison of 4a and 5a to the less hindered analogs (oxalyl chloride and oxalic acid) is used to investigate the structural features and bonding using Natural Bond Orbital (NBO) analysis.