Browsing by Creator "Roy, Ayanav"
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Item NKU Course-Based Undergraduate Research Experience: The Identification of Potential Aromatase Inhibitors Based on Computer Modeling(Northern Kentucky University) Seibert, Samuel; Roy, Ayanav; Ungar, Liat"Microwave-assisted palladium catalyzed alpha- heteroarylation reactions were performed to join tropinone with heteroaryl halide compounds 4- bromoisoquinoline and 6- bromoquinoline to obtain potential aromatase inhibitors for the treatment of breast cancer. Computer modeling reveals that both target products show high enzyme-pocket docking scores compared to other tropinone-heteroaryl products synthesized in this course-based research lab. Herein, binding pocket interactions of various tropinone-derived compounds are compared to provide a rationale for further testing of these target products."