Browsing by Creator "Clough, Katie"
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Item The History of the United Fruit Company Medical Department(Northern Kentucky University) Clough, KatieThe United Fruit Company Medical Department was formally founded in 1912, however there were already several hospitals owned an operated by the United fruit company before that. Through my Honors class I have been researching not only the creation of the United Fruit Company Medical Department but their role on shaping the world of medicine. I look at information from the first 20 published annual reports (1912-1931) regarding death rates, diseases, and patient summaries.Item Motor function changes in three genotypes of mice exposed to benzo[a]pyrene during gestation and lactation(Northern Kentucky University) Feltner, Mackenzie; Clough, Katie; Foster, Emma; Kyntchev, Angela; Towell, Aria; Patel, Shreyaben; Honaker, Amanda; Perry, Connor; Berling, Kevin"Benzo[a]pyrene (BaP) is a known carcinogen found in automobile exhaust, wood fire smoke, tobacco smoke, grilled food and coal tar. Many studies found exposure to these pollutants during pregnancy can damage genes and the placenta and impair fetal growth. We use mice that mimic human genetic variation in genes related to BaP metabolism to identify those at highest risk. In this study, we looked at motor function in adult mice exposed to BaP during gestation and lactation. We found no effect of genotype, but discovered Cyp1a2 knockout mice have deficits in motor coordination on the rotarod test."Item Using High-Performance Liquid Chromatography to Assess Genetic Susceptibility to Gestational and Lactational Benzo[a]pyrene Exposure(Northern Kentucky University) Clough, Katie; Foster, Emma; Massie, Lisa"Traffic-related air pollution is a complex mixture that includes the neurotoxic polycyclic aromatic hydrocarbon benzo[a]pyrene. We use mice to model human genetic variation in genes related to BaP metabolism to identify those at higher risk from early life exposure. Following behavioral testing of mice exposed to BaP during pregnancy and breast-feeding, we measure neurotransmitter levels in multiple brain regions. We found significant differences in levels of both dopamine and serotonin and their metabolites. The greatest changes were in the hippocampus which has a critical role in learning and memory and the prefrontal cortex which is required for normal cognitive function."