Possible Aromatase Inhibitors: Testing the Synthesis and Creating a Library of Diketone Compounds

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Northern Kentucky University
The goal of our research is to produce a catalogue of diketone molecules in order to find a possible inhibitor for aromatase. To do this diketone compounds were produced in two steps by first synthesizing a base compound, and then a second step of microwave irradiation, producing a diketone. The compounds were confirmed by NMR after both steps in order to ensure synthesis was successful. A record of all products were catalogued to show successful and unsuccessful compounds/diketones.
2020 Celebration of Student Research and Creativity presentation
Aromatase, Ketones, Chemical inhibitors