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Using High-Performance Liquid Chromatography to Assess Genetic Susceptibility to Gestational and Lactational Benzo[a]pyrene Exposure

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dc.contributor.author Clough, Katie
dc.contributor.author Foster, Emma
dc.contributor.author Massie, Lisa
dc.date.accessioned 2021-10-12T16:55:24Z
dc.date.available 2021-10-12T16:55:24Z
dc.date.created 2021
dc.identifier.uri http://hdl.handle.net/11216/4001
dc.description.abstract "Traffic-related air pollution is a complex mixture that includes the neurotoxic polycyclic aromatic hydrocarbon benzo[a]pyrene. We use mice to model human genetic variation in genes related to BaP metabolism to identify those at higher risk from early life exposure. Following behavioral testing of mice exposed to BaP during pregnancy and breast-feeding, we measure neurotransmitter levels in multiple brain regions. We found significant differences in levels of both dopamine and serotonin and their metabolites. The greatest changes were in the hippocampus which has a critical role in learning and memory and the prefrontal cortex which is required for normal cognitive function." en_US
dc.description.tableofcontents 2021 Celebration of Student Research and Creativity presentation
dc.description.uri https://youtu.be/8Bh_jwIxTOk en_US
dc.language.iso en_US en_US
dc.publisher Northern Kentucky University en_US
dc.relation.ispartofseries Celebration of Student Research and Creativity;2021
dc.subject Air Pollution Experiments en_US
dc.subject Brain Abnormalities en_US
dc.subject Benzopyrene en_US
dc.title Using High-Performance Liquid Chromatography to Assess Genetic Susceptibility to Gestational and Lactational Benzo[a]pyrene Exposure en_US
dc.type Presentation en_US


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