Ensuring the Integrity of an HSV-Vectored Vaccine System
Date Issued
2020
Creators
Journal Title
Journal ISSN
Volume Title
Publisher
Northern Kentucky University
Abstract
Herpes simplex virus (HSV)-vectored vaccines for hepatitis C virus (HCV) were developed utilizing a bacterial artificial chromosome (BAC) system for DNA manipulations. These BAC-derived vectors allow for the rapid introduction and expression of foreign DNA in the HSV backbone. The DNA sequence of several production lots of the vaccine is currently being determined to confirm the genetic stability of the vaccine. While the initial vaccine target was hepatitis C virus, genes from any infectious virus, such as novel coronaviruses, could be inserted into this vaccine vector to generate immunity to that agent.
Description
2020 Celebration of Student Research & Creativity presentation
Type
Presentation
Format
Keywords
Herpes simplex virus, Vaccines Biotechnology, Hepatitis C virus, Bacterial artificial chromosomes, Gene rearrangement